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Results: 6


Lucia Banci
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STEM area: Chemistry

Competences:

Keywords:

Region: Tuscany


Position/Role

Lucia Banci is Professor of Chemistry at the University of Florence.

Professional career

She graduated in Chemistry at the University of Florence in 1978, and continued her training through various research periods abroad, mainly in the USA. She continued her academic career at the University of Florence, first as a researcher and in 1987 as Associate Professor. Since 1999 she is Full Professor of General and Inorganic Chemistry and, from 2011 to 2017, she has been Director of CERM (Magnetic Resonance Center) of the University of Florence. Lucia Banci is the Head of the Italian Core Center of the ESFRI Research Infrastructure Instruct-ERIC, and a member of the Instruct-ERIC Executive Committee and of the Council.

Scientific results

Lucia Banci has provided and is providing original and innovative contributions in structural biology and nuclear magnetic resonance (NMR) applied to biological systems. In particular, she has gained visibility as an international leader for the characterization of functional processes in living cells with atomic-level resolution. She applied and is applying this approach to the study of the processes responsible for the transport and use of metal ions, in particular copper and iron. She has developed innovative approaches for "in cell NMR", ie high resolution NMR in living cells, which allows the characterization of human proteins in living human cells at atomic resolution. Lucia Banci is contributing to the development and use of high resolution nuclear magnetic resonance (NMR) spectroscopy, a research field in which she has provided important theoretical and methodological advances. She has been active in research projects of structural genomics, in which she uses a "functional" approach, that is, she exploits the knowledge of the conformation of the biomolecules to understand their function and how it can be altered by mutations or other alterations. She has also been a pioneer in the development of an absolutely innovative approach for the rational design of highly effective vaccines, ie the structural vaccinology, based on the structural characterization of the antigens and their interaction with the antibodies.

Editorial work and publications

She has published about 400 research articles on peer reviewed journals with a total of 21.000 citations.

A few relevant publications:


(2018) Luchinat E, BanciL. In-Cell NMR in Human Cells: Direct Protein Expression Allows Structural Studies of Protein Folding and Maturation. Acc Chem Res., 51, 1550-1557.

(2016) Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Camponeschi F, Ciofi-Baffoni S, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Stessman HAF, Marchetto MCN, Denman L, Harshman L, Baker C, Raja A, Penewit K, Tang WJ, Ventura M, Antonacci F, Akey JM, Amemiya CT, Banci L, Gage FH, Reymond A and Eichler EE. Emergence of a Homo sapiens-specific gene family and the evolution of autism risk at chromosome 16p11.2. Nature, 536:205-209.

(2015) Banci L, Ciofi-Baffoni S, Gajda K, Muzzioli R, Peruzzini R and Winkelmann J. N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin. Nature Chemical Biology, 11:772-778.

(2011) Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley M.J, Malito E, Lo Surdo P, Comanducci M, Giuliani M.M, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M. & Rappuoli R, Rational design of a meningococcal antigen inducing broad protective immunity. Science Translational Medicine, 3:91ra62.

(2010) Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K & Palumaa P. Affinity gradients drive copper to cellular destinations. Nature, 465:645-648

Awards and prizes

During her career she has received prizes and awards, among which the IUPAC "Distinguished Women in Chemistry" award and the "Fiorino d’Oro della Città di Firenze" Gold Medal of the City of Florence in 2015. In 2017 she received the “Instruct Bertini Award” for Integrated Structural Biology and the Premio Scienza Madre in 2018. She is a member of EMBO (European Organization for Molecular Biology) and is the Italian delegate at the Council of the European Molecular Biology Laboratory (EMBL).

 

Paola Fermo
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STEM area: Chemistry

Competences:

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Region: Lombardy

Maria Costanza Rovida
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STEM area: Chemistry

Competences:

Keywords: regolamento reach

Region: Lombardy

Marika Savarese
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STEM area: Chemistry

Competences:

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Region: Liguria

Luisa Torsi
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STEM area: Chemistry

Competences:

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Region: Apulia

Margherita Venturi
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STEM area: Chemistry

Competences:

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Region: Emilia-Romagna