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Results: 7


Lucia Banci
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STEM area: Chemistry

Competences: chemistry, MRI

Keywords: copper transport in cells, iron, metal proteins, metals in biological systems, MRI, structural biology, vaccine design

Region: Tuscany


Position/Role

Lucia Banci is Professor of Chemistry at the University of Florence.

Professional career

She graduated in Chemistry at the University of Florence in 1978, and continued her training through various research periods abroad, mainly in the USA. She continued her academic career at the University of Florence, first as a researcher and in 1987 as Associate Professor. Since 1999 she is Full Professor of General and Inorganic Chemistry and, from 2011 to 2017, she has been Director of CERM (Magnetic Resonance Center) of the University of Florence. Lucia Banci is the Head of the Italian Core Center of the ESFRI Research Infrastructure Instruct-ERIC, and a member of the Instruct-ERIC Executive Committee and of the Council.

Scientific results

Lucia Banci has provided and is providing original and innovative contributions in structural biology and nuclear magnetic resonance (NMR) applied to biological systems. In particular, she has gained visibility as an international leader for the characterization of functional processes in living cells with atomic-level resolution. She applied and is applying this approach to the study of the processes responsible for the transport and use of metal ions, in particular copper and iron. She has developed innovative approaches for "in cell NMR", ie high resolution NMR in living cells, which allows the characterization of human proteins in living human cells at atomic resolution. Lucia Banci is contributing to the development and use of high resolution nuclear magnetic resonance (NMR) spectroscopy, a research field in which she has provided important theoretical and methodological advances. She has been active in research projects of structural genomics, in which she uses a "functional" approach, that is, she exploits the knowledge of the conformation of the biomolecules to understand their function and how it can be altered by mutations or other alterations. She has also been a pioneer in the development of an absolutely innovative approach for the rational design of highly effective vaccines, ie the structural vaccinology, based on the structural characterization of the antigens and their interaction with the antibodies.

Editorial work and publications

She has published about 400 research articles on peer reviewed journals with a total of 21.000 citations.

A few relevant publications:


(2018) Luchinat E, BanciL. In-Cell NMR in Human Cells: Direct Protein Expression Allows Structural Studies of Protein Folding and Maturation. Acc Chem Res., 51, 1550-1557.

(2016) Nuttle X, Giannuzzi G, Duyzend MH, Schraiber JG, Narvaiza I, Camponeschi F, Ciofi-Baffoni S, Sudmant PH, Penn O, Chiatante G, Malig M, Huddleston J, Benner C, Stessman HAF, Marchetto MCN, Denman L, Harshman L, Baker C, Raja A, Penewit K, Tang WJ, Ventura M, Antonacci F, Akey JM, Amemiya CT, Banci L, Gage FH, Reymond A and Eichler EE. Emergence of a Homo sapiens-specific gene family and the evolution of autism risk at chromosome 16p11.2. Nature, 536:205-209.

(2015) Banci L, Ciofi-Baffoni S, Gajda K, Muzzioli R, Peruzzini R and Winkelmann J. N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin. Nature Chemical Biology, 11:772-778.

(2011) Scarselli M, Aricò B, Brunelli B, Savino S, Di Marcello F, Palumbo E, Veggi D, Ciucchi L, Cartocci E, Bottomley M.J, Malito E, Lo Surdo P, Comanducci M, Giuliani M.M, Cantini F, Dragonetti S, Colaprico A, Doro F, Giannetti P, Pallaoro M, Brogioni B, Tontini M, Hilleringmann M, Nardi-Dei V, Banci L, Pizza M. & Rappuoli R, Rational design of a meningococcal antigen inducing broad protective immunity. Science Translational Medicine, 3:91ra62.

(2010) Banci L, Bertini I, Ciofi-Baffoni S, Kozyreva T, Zovo K & Palumaa P. Affinity gradients drive copper to cellular destinations. Nature, 465:645-648

Awards and prizes

During her career she has received prizes and awards, among which the IUPAC "Distinguished Women in Chemistry" award and the "Fiorino d’Oro della Città di Firenze" Gold Medal of the City of Florence in 2015. In 2017 she received the “Instruct Bertini Award” for Integrated Structural Biology and the Premio Scienza Madre in 2018. She is a member of EMBO (European Organization for Molecular Biology) and is the Italian delegate at the Council of the European Molecular Biology Laboratory (EMBL).

 

Paola Fermo
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STEM area: Chemistry

Competences: analytical chemistry, environmental chemistry

Keywords: air pollution, cultural heritage, emissions, environment, pollution, water

Region: Lombardy


Position/Role

ASSOCIATIONS

Member of SCI (Divisione di Chimica Analitica e Divisione di Chimica dell’Ambiente e dei Beni Culturali)

AIAR (Italian Association of Archaeometry), ACE (Association of Chemistry and the Environment)

Secretary of the SCI Interdivisional Group of Aerosol Science and Technologies  (2009-2012)

Member of consortium INSTM (consorzio internazionale per la scienza e la tecnologia dei materiali)

Member of CRC (centro di ricerca coordinato) Beni Culturali, University of Milan (http://www.crc-beniculturali.unimi.it)

 

SCIENTIFIC COMMITTEES

Member of the scientific committee of the Workshop “Sustainable knowledge and preservation of Cultural Heritage for future generations”; 2-4/05/2016, E-MRS (Materials Research Society) Spring Meeting, Lille (France)

 

Organizer of the section entitled: Measurements for ceramics and glasses

International congress: Metrology for Archaeology, 19-21/10/2016, Torino

 

Member of the scientific committee of YOCOCU congress (Youth in Conservation of Cultural Heritage), Matera, 23-25/05/2018

 

Member of the scientific committee of SIMA (Società Italiana di Medicina Ambientale) (http://www.simaonlus.it)

Professional career

1993    Degree in Chemistry, University of Milan (110/110)

1997    PhD in Chemistry, University of Milan

1997– 1999 Technical collaborator in the Department of Inorganic, Metallorganic and   Analytical Chemistry,  University of Milan

1999 – 2014 Researcher in Analytical Chemistry, Department of Inorganic, Metallorganic and  Analytical Chemistry, University of Milan

since 2015 - Associate Professor of Analytical Chemistry, Department of Chemistry, University of Milan

National Scientific qualification (ASN) as PO:  sector 03/A1 – SSD CHIM01 (call 2016-2018, primo quadrimestre)

Scientific results

Atmospheric and environmental chemistry:

Characterization of aerosol particulate matter (PM) carried out by different analytical techniques for the quantification and speciation of main species (carbonaceous fraction and ions); analysis of specific markers for the identification of aerosol PM sources.

Effect of environmental pollution on cultural heritage: study of black crust present on historical monuments in polluted environments; indoor air quality assessment  in museums and art galleries.

Chemical characterization of biomarkers of environmental pollution (honey or plant leaves); food analysis and food safety control.

 

Analytical chemistry applied to cultural heritage:

provenance and technological study of archaeological and Renaissance ceramics, paintings, mortars, etc.; new coatings based on nano-materials for the protection of materials of artistic-historical-interest (marbles, mortars).

 

Editorial work and publications

110 scientific publications on international peer-review journals (Scopus and Web of Science) in the field of environmental and analytical chemistry as well as archaeometry; 20 conference proceeding; 16 book chapters; more than 200 communications in national and international congresses; invited speakers in national and international congresses.

h-index=28

More then Citations= 2384

applicate ai settori ambientale, beni culturali e alimentare”, 21/06/2005, Milan

 

TEACHING ACTIVITY

Adjoint Professor 2001-2013;

since 2015 Associate Professor of Analytical Chemistry (CHIM01).  Scince 1999 teaching activity for undergraduate and graduate courses leading to Bachelor of Science (BS) and Master of Science (MS) degrees in Chemistry and Industrial Chemistry

Member of the board of professors of PhD in Chemistry, University of Milan; supervisor of students (more than 60 Master’s theses in Chemistry; supervisor of 4 PhD students)

Teaching activity for PhD: 2003-2016

 

Recent Publications (2017-2018)

 

(2019) Ielpo, P., Mangia, C., Marra, G.P., Comite, V., Rizza, U., Uricchio, V.F., Fermo, P.

Outdoor spatial distribution and indoor levels of NO2 and SO2 in a high environmental risk site of the South Italy

Science of the Total Environment, 648, pp. 787-797.

 

(2018) Paola Fermo, Sara Goidanich, Valeria Comite, Lucia Toniolo, Davide Gulotta, Study and characterization of environmental deposition on marble and surrogate substrates at a monumental heritage site;Geosciences; in press

(2018) Maria Letizia Amadori, Valentina Raspugli, Valeria Comite, Paola Fermo, Francesco Maria Mini, Mauro La Russa, Yoshifumi Maekawa,

Integrated Scientific Investigations On Constitutive Materials From Me-taw-ya Temple, Pagán Valley, Burma (Myanmar),Measurement,ISSN 0263-2241,https://doi.org/10.1016/j.measurement.2018.09.004; in press

 

(2018) Amadori, M.L., Pallante, P., Fermo, P., Emami, M.A., Chaverdi, A.A., Callieri, P., Matin, E.

Advances in Achaemenid brick manufacturing technology: Evidence from the monumental gate at Tol-e Ajori (Fars, Iran)

Applied Clay Science, 152, pp. 131-142.

 

(2018) Vecchi, R., Bernardoni, V., Valentini, S., Piazzalunga, A., Fermo, P., Valli, G.

Assessment of light extinction at a European polluted urban area during wintertime: Impact of PM1 composition and sources

Environmental Pollution, 233, pp. 679-689.

 

(2018) Daellenbach, K.R., El-Haddad, I., Karvonen, L., Vlachou, A., Corbin, J.C., Slowik, J.G., Heringa, M.F., Bruns, E.A., Luedin, S.M., Jaffrezo, J.-L., Szidat, S., Piazzalunga, A., Gonzalez, R., Fermo, P., Pflueger, V., Vogel, G., Baltensperger, U., Prévôt, A.S.H.

Insights into organic-Aerosol sources via a novel laser-desorption/ionization mass spectrometry technique applied to one year of PM10 samples from nine sites in central Europe

Atmospheric Chemistry and Physics, 18 (3), pp. 2155-2174.

 

(2017) Bernardoni, V., Elser, M., Valli, G., Valentini, S., Bigi, A., Fermo, P., Piazzalunga, A., Vecchi, R.

Size-segregated aerosol in a hot-spot pollution urban area: Chemical composition and three-way source apportionment

Environmental Pollution, 231, pp. 601-611. Cited 1 time.

 

(2017) Daellenbach, K.R., Stefenelli, G., Bozzetti, C., Vlachou, A., Fermo, P., Gonzalez, R., Piazzalunga, A., Colombi, C., Canonaco, F., Hueglin, C., Kasper-Giebl, A., Jaffrezo, J.-L., Bianchi, F., Slowik, J.G., Baltensperger, U., El-Haddad, I., Prévôt, A.S.H.

Long-term chemical analysis and organic aerosol source apportionment at nine sites in central Europe: Source identification and uncertainty assessment

Atmospheric Chemistry and Physics, 17 (21), pp. 13265-13282.

 

(2017) La Russa, M.F., Fermo, P., Comite, V., Belfiore, C.M., Barca, D., Cerioni, A., De Santis, M., Barbagallo, L.F., Ricca, M., Ruffolo, S.A.

The Oceanus statue of the Fontana di Trevi (Rome): The analysis of black crust as a tool to investigate the urban air pollution and its impact on the stone degradation

Science of the Total Environment, 593-594, pp. 297-309.

 

(2017) Marabini, L., Ozgen, S., Turacchi, S., Aminti, S., Arnaboldi , F., Lonati , G., Fermo , P., Corbella , L., Valli , G., Bernardoni , V., Dell'Acqua , M., Vecchi , R., Becagli , S., Caruso, D., Corrado , L.G., Marinovich , M.

Ultrafine particles (UFPs) from domestic wood stoves: genotoxicity in human lung carcinoma A549 cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis, 820, pp. 39-46.

 

(2017) Bozzetti, C., El Haddad, I., Salameh, D., Daellenbach, K.R., Fermo, P., Gonzalez, R., Minguillón, M.C., Iinuma, Y., Poulain, L., Elser, M., Müller, E., Slowik, J.G., Jaffrezo, J.-L., Baltensperger, U., Marchand, N., Prévôt, A.S.H.

Organic aerosol source apportionment by offline-AMS over a full year in Marseille

Atmospheric Chemistry and Physics, 17 (13), pp. 8247-8268.

 

(2017) Amadori, M.L., Del Vais, C., Fermo, P., Pallante, P.

Archaeometric researches on the provenance of Mediterranean Archaic Phoenician and Punic pottery

Environmental Science and Pollution Research, 24 (16), pp. 13921-13949.

 

(2017) Corsini, E., Vecchi, R., Marabini, L., Fermo, P., Becagli, S., Bernardoni, V., Caruso, D., Corbella, L., Dell'Acqua, M., Galli, C.L., Lonati, G., Ozgen, S., Papale, A., Signorini, S., Tardivo, R., Valli, G., Marinovich, M.

The chemical composition of ultrafine particles and associated biological effects at an alpine town impacted by wood burning

Science of the Total Environment, 587-588, pp. 223-231.

 

(2017) Pino, F., Fermo, P., La Russa, M., Ruffolo, S., Comite, V., Baghdachi, J., Pecchioni, E., Fratini, F., Cappelletti, G.

Advanced mortar coatings for cultural heritage protection. Durability towards prolonged UV and outdoor exposure

Environmental Science and Pollution Research, 24 (14), pp. 12608-12617.

 

(2017) Bigi, A., Bianchi, F., De Gennaro, G., Di Gilio, A., Fermo, P., Ghermandi, G., Prévôt, A.S.H., Urbani, M., Valli, G., Vecchi, R., Piazzalunga, A.

Hourly composition of gas and particle phase pollutants at a central urban background site in Milan, Italy

Atmospheric Research, 186, pp. 83-94.

 

(2017) Ozgen, S., Becagli, S., Bernardoni, V., Caserini, S., Caruso, D., Corbella, L., Dell'Acqua, M., Fermo, P., Gonzalez, R., Lonati, G., Signorini, S., Tardivo, R., Tosi, E., Valli, G., Vecchi, R., Marinovich, M.

Analysis of the chemical composition of ultrafine particles from two domestic solid biomass fired room heaters under simulated real-world use

Atmospheric Environment, 150, pp. 87-97. Cited 7 times.

 

(2017) Benetello, F., Squizzato, S., Hofer, A., Masiol, M., Khan, M.B., Piazzalunga, A., Fermo, P., Formenton, G.M., Rampazzo, G., Pavoni, B.

Estimation of local and external contributions of biomass burning to PM2.5 in an industrial zone included in a large urban settlement

Environmental Science and Pollution Research, 24 (2), pp. 2100-2115. 

(2017) Chiara Pietrogrande, M., Barbaro, E., Bove, M.C., Clauser, G., Colombi, C., Corbella, L., Cuccia, E., Dalla Torre, S., Decesari, S., Fermo, P., Gambaro, A., Gianelle, V., Ielpo, P., Larcher, R., Lazzeri, P., Massabò, D., Melchionna, G., Nardin, T., Paglione, M., Perrino, C., Prati, P., Visentin, M., Zanca, N., Zangrando, R.

Results of an interlaboratory comparison of analytical methods for quantification of anhydrosugars and biosugars in atmospheric aerosol

Chemosphere, 184, pp. 269-277. 

(2017) Corsini E, Ozgen S, Papale A, Galbiati V, Lonati G, Fermo P, Corbella L, Valli G, Bernardoni V, Dell'Acqua M, Becagli S, Caruso D, Vecchi R, Galli CL, Marinovich M. Insights on wood combustion generated proinflammatory ultrafine particles (UFP). Toxicology Letters, 266, 74-84.

Simonetta Gallerini
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STEM area: Chemistry

Competences: industrial chemistry, total quality management

Keywords: business model canvas, Kaizen Monozukuri WG, Lean, risk assessment, Six Sigma, Toyota Way

Region: ABROAD


Position/Role

Quality Assurance in SAGEA Centro di Saggio Srl, International Contract Research Organisation and International Consultant for TQM and Lean Six Sigma projects at COMATCH GmbH Berlin.

Professional career

After the Master Degree in Chemistry (Industrial Chemistry sector) at the University of Florence Industrial Organic Chemistry Dep. (1999) and one fellowship at the ConsorzioC.I.R.M.M.P.Consorzio Interuniversitario per la ricerca sulle Metallo-ProteineUniversity of Florence, she has many working expertise in topics related to the study and improvement of company processes and analytical methods: Pharma at the Eli Lilly Italy Medical Area, Environment at the ARPAT Dep. Waste and Soil Remediation, C.T.A. Srl Environmental Consulting.

From 2000 to 2017 Technical Consultant of the Law Court of Florence.

From 2003 to May 2008, she worked at the ALPHA ECOLOGIA Srl to reach the Accreditation ISO17025 by ACCREDIA, company processes and lab activities continuous improvement.

From 2006 she was a Certified Internal Auditor for the Quality Management System (ISO19011), skills certificated by CSQA. 

From May 2008 to February 2016 she worked in Biochemielab Srl: first as Head Lab Manager, to implement the Quality Management System with process approach, to implement the QA/QC EPA Standard Quality System, continuous improvement of the Accreditation ISO17025 by ACCREDIA, digitization lab activities; afterwards as Lead Quality Assurance Manager working to quality-environment-safety integrated system, ISO9001 and ISO14001 certification, Accreditation ISO17025 by ACCREDIA, continuous improvement of company processes.

Since March 2016, she works in SAGEA Centro di Saggio Srl, an International Contract Research Organisation in Agrifood, as Quality Assurance Manager; dealing with GLP and GEP certification as internal auditor; she has implemented the Quality Management System ISO9001, process approach of Japanese model of Total Quality Management and now she’s working to improve the company processes with the help of Lean Six Sigma methodologies.

Since 2016 she is Italian President of Food sector of AICQ (Associazione Italiana Cultura Qualità) for the Quality diffusion in the Agri-food sector and Italian vice-president of AICQ Calibration and Testing Laboratory Committee for the Quality diffusion in the laboratories.

Since 2019 she is Green Belt Six Sigma and she is an International Consultant for TQM and Lean Six Sigma Projects at the COMATCH GmbH located in Berlin.

Scientific results

Since 2000 expertise in company implementation of Japanese model of Total Quality Management(Toyota Way), continuous improvement Kaizen, company processes analyse and Lean Six Sigma Projects, company organization of MonozukuriWG. 

On 2013 she partecipated as speaker at following Conferences:

  • Quality-Day “Fare qualità oggi nel laboratorio analisi delle acque, Accreditamento delle metodiche test in cuvetta per le analisi delle acque” with title “L’esperienza per la misura del COD”, HACHLANGE-ACCREDIA, Florence
  • Plenaria Congiunta “Idrocarburi in matrici ambientali”, IDRO 2012, with title “ISO 16703:2004 e EPA 8015D 2003 due metodi a confronto per la determinazione del parametro C12-C40”, UNICHIM, Milan
  • “Validazione di un metodo interno per un laboratorio privato”, with title “Metodo interno MP015: determinazione di istamina nel pesce fresco e conservato”, ALA/ACCREDIA/ARPA Marche, Pesaro

 

Since 2016 her AICQ activity allowed to participate at many Conferences with Istituto Superiore di Sanità, ACCREDIA, AICQ-SICEV:

  • 2016-2017 Working Group AICQ/ACCREDIA to revise ISO17025 Standard, Padua 
  • 2017, Speaker and Scientific Responsible “I PRINCIPI DI BUONA PRATICA DI LABORATORIO E LA CERTIFICAZIONE DEI CENTRI DI SAGGIO” in collaboration with Istituto Superiore di Sanità, Bologna
  • 2017, Conference AICQ-ACCREDIA “LA NUOVA NORMA ISO 17025:2017 PER I LABORATORI DI PROVA E DI TARATURA”, Padua
  • 2017 Speaker and Responsible for the Seminar “FSSC22000 v.4.1: REQUISITI E COME SODDISFARLI”, AICQ-CN Milan
  • 2018 creation and validation of the Training Course AICQ-SICEV for Auditor/Lead Auditor Quality Management System (40 hours) AgriFood sector – Bio products, ISO9001, D.Lgs. n.20 23/02/2018
  • 2018, Working Group for the Training Course AICQ-SICEV “Le innovazioni della nuova ISO 19011:2018” (16 hours)
  • Since 2018 she is Member UNI/CT 003 "Agrifood commission” with the right to vote, member UNI/CT003/GL21 "Biostimulants" with the right to vote, member UNI/CT406 “Fertilizers” with the right to vote, member UNI/CT003/GL23 “Food Authenticity” with the right to vote.

Since 2019 she is one of theResponsible of the Training European Project ENVIRECA-ERASMUS+ with partnership of European Commission, AICQ, DU, FLA, HRC, CSM and EXELIA “Cooperation for innovation and the exchange of good practices, Strategic Partnerships for vocational education and training” in the HORECA sector.

Maria Costanza Rovida
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STEM area: Chemistry

Competences: alternatives to animal experiments, chemicals dossier, chromatography, cosmetic components, validation of new methods

Keywords: animal experiments, animal feed, animal testing, cosmetics, in vitro tests, official toxicological methods, reach regulation

Region: Lombardy


Position/Role

Scientific Officer at CAAT-Europe (University of Konstanz, Germany, Project Manager at TEAM Mastery)

Professional career

After her master degree in Chemistry with bio-organic specialisation at the University of Milan in 1989, she worked for 10 months in Germany as a chemist trainee at the Hewlett Packard (now Agilent Technology). The following years, she started as Chromatography Applicant specialist to investigate components in complex mixtures. For 15 years, she worked as analytical manager in national and international companies and in 2005 she joined the European Commission for a three year program at ECVAM, the European Centre for Validation of Alternative Methods where she participated in the working group RIP 3.3 (REACH Implementation Project, Technical Guidelines to Industries) and coordinated the integrated European Project Sens-it-iv, for the development of in vitro and in silico methods for the assessment of skin sensitisation. Since 2009 she has been appointed as Scientific Officer at CAAT - Europe (Centre for Alternatives to Animal Testing) at the Konstanz University in Germany, in collaboration with the John Hopkins University in Baltimora (USA). For 10 years, Costanza Rovida has been also Project Manager at TEAM Mastery, a consultancy company in the business of regulatory affairs for chemistry, with special focus on REACH Regulation, that implements safe use of chemicals in the EU to improve human and environment health

Scientific results

Costanza Rovida has been committed in the evaluation of strategies to reduce or avoid the use of animals for scientific purposes. As Project Manager at TEAM Mastery and expert in testing strategies, she is also responsible for the preparation of registration dossiers of chemical substances, or for the toxicological evaluation of food/feed ingredients or cosmetics products in compliance with EU or non-EU legislation. Costanza Rovida is educator at the Association for Environment and workers taking care of safety in compliance with the provisions of both REACH and CLP (Regulations about how to communicate and manage the risk related to the handlings of chemicals). Her main commitment still lays in the dissemination and promotion of innovative human-based methods that are not using animals, through the organisation of workshops and publication of scientific papers as well as the spread of safety culture in compliance with international guidelines or with (International Conference on Harmonisation), with FDA (Food and Drug Administration) in collaboration with ECVAM, the European Centre for Validation of Alternative Methods.

Editorial work and publications

She is the author of many peer review publication, including: 

(2018) Meigs L., Smirnova L., Rovida C., Leist M. and Hartung T. Animal Testing and its Alternatives – the Most Important Omics is Economics. ALTEX  35(3) 275-305

(2016) Luechtefeld T, Maertens A, Russo DP, Rovida C, Zhu H and Hartung T. Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014. ALTEX 33(2), 95-109

(2015) Rovida C, Asakura S, Daneshian M, Hofman-Huether H, Leist M, Meunier L, Reif D, Rossi A, Schmutz M, Valentin JP, Zurlo J, Hartung T. Toxicity testing in the 21st century beyond environmental chemicals. ALTEX Alternatives to Animal Experimentation, 32(3):171-81. 

(2015) Rovida C, Alépée N, Api AM, Basketter DA, Bois FY, Caloni F, Corsini E, Daneshian M, Eskes C, Ezendam J, Fuchs H, Hayden P, Hegele-Hartung C, Hoffmann S, Hubesch B, Jacobs MN, Jaworska J, Kleensang A, Kleinstreuer N, Lalko J, Landsiedel R, Lebreux F, Luechtefeld T, Locatelli M, Mehling A, Natsch A, Pitchford JW, Prater D, Prieto P, Schepky A, Schuurmann G, Smirnova L, Toole C, van Vliet E, Weisensee D, Hartung T. Integrated Testing Strategies (ITS) for safety assessment. ALTEX Alternatives to Animal Experimentation, 32(1): 25-40. 

(2014) Rovida C, Vivier M, Garthoff B, Hescheler J. ESNATS Conference — The Use of Human Embryonic Stem Cells for Novel Toxicity Testing Approaches. ATLA Alternatives to Laboratory Animals, 42, 97-113. 

(2014) Knight J, Rovida, C. Safety Evaluations under the Proposed US Safe Cosmetics and Personal Care Products Act of 2013: Animal Use and Cost Estimates. ALTEX Alternatives to Animal Experimentation, 31(2):177-208.

(2013) Rovida C, De Angelis I, Lorenzetti S. Alternative in vitro methods to characterize the role of Endocrine Active Substances (EASs) in hormone-targeted tissues. ALTEX Alternatives to Animal Experimentation, 30(2):253-5. 

(2011) Rovida C, Longo F, Rabbit RR. How are Reproductive Toxicity and Developmental Toxicity Addressed in REACH Dossiers? ALTEX Alternatives to Animal Experimentation, 28(3), 111-132. 

(2010) Rovida C. Food for Thought... Why No New In Vitro Tests Will Be Done for REACH by Registrants. ALTEX, Alternatives to Animal Experimentation, 27(3), 175-183. 
(2009) Hartung T, Rovida C. Opinion. Chemical regulators have overreached. Nature, 460, 1080-1.

Awards and prizes

Costanza Rovida is in the list of National Certified Toxicologists Register (RENTIC) and Accredited Stakeholder at the European Chemicals Agency (ECHA) and at the European Food Safety Authority (EFSA). She is in the expert group of the National Reference Centre for Alternative Methods (Istituto Zooprofilattico di Brescia), of ESTAF (ECVAM Stakeholder Forum), IPAM (Italian Platform for Alternative Methods) and secretary of ecopa (European Platform for Alternative Methods). She is also member of several scientific societies such as ESTIV (European Society of in vitro testing), SITOX (Italian Society Italiana of Toxicology) and AFI (Italian Associazione of Pharma). She is in the list of STOA consultant (European Parliament Science and Technology Options Assessment).

 

Marika Savarese
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STEM area: Chemistry

Competences: innovative computational tools, theoretical and computational chemistry

Keywords: light, photochemistry, photophysics, solar cells

Region: Liguria


Position/Role

Researcher at the D3 Compunet Department of the Italian Institute of Technology (IIT) in Genoa.

Professional career

After graduating in Chemical Science in 2008 and a master’s degree in Chemistry in 2010 at the Federico II University in Naples, she continued with her studies with a PhD she obtained in 2014 from the same University. Meanwhile, she worked for the Italian Institute of Technology at the Center for Advanced Health Biomaterials at the CRIB (Interdepartmental Research Center on Biomaterials) in Naples. After the PhD, she worked with the CTM team of Professor Adamo at the École Nationale Supérieure de Chimie de Paris (ENSCP). In the same year, 2014, she was Visiting Researcher at the Research Center for Computational Sciences of the Institute of Molecular Science of Okazaki in Japan.
Since 2015 she is a Post-doc Researcher at the IIT of Genoa.

 

Scientific results

Marika Savarese deals with theoretical modeling, supported by computational approaches based on the Density Functional Theory (DFT), of phenomena of chemical-physical interest; in particular, the development of new protocols for the description of phenomena concerning light-matter interaction. These approaches are useful in the fields of photophysics and photochemistry, and they are applicable, for example, in the interpretation of electronic spectroscopies and in the study of reaction mechanisms promoted by light. These models make it possible to carry out design and “in silico” screening steps (by using the computer) that allow the planning of new technological devices in a targeted way. Results in this sense have been achieved for the design and construction of new biosensors and new materials used for the construction of solar cells entirely made of material.

 

Editorial work and publications

She is author and co-author of numerous scientific publications including:

 

[2017] Savarese M, Raucci U, Fukuda R, Adamo C, Ehara M, Rega N, Ciofini I. Comparing the performance of TDDFT and SACCI methods in the description of excited states potential energy surfaces: An excited state proton transfer reaction as case study. Journal

of Computational Chemistry, 38:1084.

 

[2016] Savarese M, Brémond È, Rega N, Adamo C, Ciofini I. Excited State Proton Transfer and Intramolecular Charge Transfer in 1, 3 diketone Molecules: a Density Functional Theory Based investigation. ChemPhysChem, 17:1530.

 

[2016] Savarese M, Brémond È, Adamo C.Exploring the limits of recent exchange–correlation functionals in modeling lithium/benzene interaction.Theoretical Chemistry Accounts, 145:1.

 

[2016] Savarese M, Raucci U, Netti PA, Adamo C, Rega N, Ciofini I. A Qualitative Model to Identify Non Radiative Decay channels: the Spiropyran as case study

Theoretical Chemistry Accounts,135:211.

 

[2015] Savarese M, Brémond È, Antonov A, Ciofini I, Adamo C, Computational Insights into ExcitedState ProtonTransfer Reactions in Azo and Azomethine Dyes.ChemPhysChem,16:3966.

 

[2015] Bonaccorso F, Balis N, Stylianakis MM, Savarese M, Adamo C, Gemmi M, Pellegrini V, Stratakis E, Kymaki E. Functionalized Graphene as an ElectronCascade Acceptor for AirProcessed Organic Ternary Solar Cells.Advanced Functional Materials, 25:3870.

 

[2014] Savarese M, Raucci U, Adamo C, Netti PA, Ciofini I, Rega N (Editor's Choice). Modeling of charge transfer Processes to understand photophysical signatures: The case of Rhodamine 110.Chemical Physics Letters, 610:148.

 

[2014] Savarese M, Netti PA, Rega N, Adamo C, CiofiniI. Intermolecular proton shuttling in excited state proton transfer reactions: insights from theory.Physical Chemistry Chemical Physics,16:8661.

 

[2013]Savarese M, Netti PA, Adamo C, Rega N, CIofini I, Exploring the Metric of Excited State Proton Transfer Reaction.The Journal of Physical Chemistry B,117:16165.

 

[2012] Savarese M, Aliberti A, De Santo I, Battista E, Causa F, Netti PA, Rega N.Fluorescence Lifetimes and Quantum Yields of Rhodamine Derivatives: New Insights from Theory and Experiment. The Journal of Physical Chemistry A,116:7491.

 

 

 

Luisa Torsi
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STEM area: Chemistry

Competences: analytical chemistry, bioelectronics, diagnostics, materials science and technology

Keywords: analytical chemistry, bioelectronics, biosensors, environment, inventions, materials science, nanotechnologies, odor machine, sensors, women and science

Region: Apulia


Position/Role

Full professor of Chemistry at the University of Bari (Italy)

Adjunct professor at the Abo Academy University in Finland

Professional career

Torsi received her laurea degree in Physics from the University of Bari in 1989 and the PhD in Chemical Sciences from the same institution in 1993.  She was post-doctoral fellow at Bell Labs from 1994 to 1996. In 2005 and 2006 she was invited professor at the University of Anger and Paris 7, respectively.

Scientific results

One of the main feature that characterize Torsi’s scientific excursus is the proven ability to span different interrelated fields by contributing to topics such as: electronic and electrochemical sensors, organic semiconductors, analytical chemistry, solid-state device physics, material chemistry and physics, bio-chemical interactions, gathering insights through the cross-contaminations from all these fields. This attitude stems directly from the interdisciplinary education path pursued. She contributed to study organic field-effect transistors (OFETs) fundamental electronic properties, demonstrating of the two-dimensional and bi-polar transport in such devices. In 2000 she pioneered the use of OFETs as multi-parametric chemical sensors. Afterwards, the OFETs were exploited for ultra-sensitive molecular assay by means of devices capable to perform chiral differential detection at unprecedented low concentration. Lately, she engaged in a new frontier by studying how to integrate fully functioning bio-recognition elements into OFET devices to study the properties of bio-organic interfaces, also with an extremely sensitive capacity modulated electrolyte gated OFET both able to routinely reach picomolar detection levels. The understanding of the subtlest functional details of the electronic sensor proposed has enabled to reach better and better performance leading, lately, to the demonstration of single molecule detection with a large-area processable, millimeter-sized thin-film transistor.

Editorial work and publications

Torsi has authored almost 200 ISI papers, including papers published in Science, Nature Materi-als, Nature Communications, PNAS and is co-inventor of several awarded international patents. Her works gathered almost 11.000 Google scholar citations resulting in an h-index of 50 (ISI h-index: 43).

(2018) Macchia, E., Manoli, K., Holzer, B., Di Franco, C., Ghittorelli, M., Torricelli, F., Alberga, D., Mangiatordi, G.F., Palazzo, G., Scamarcio, G., Torsi, L.* Single mo-lecule detection with a millimetre-sized transistor.Nature Communications 2018, 9, Article Number: 3223; Highlighted in Nature: https://www.nature.com/articles/d41586-018-05950-z

(2017) Holzer., B., Manoli, K., Ditaranto, N., Macchia, E., Tiwari, A., Di Franco, C., Scamarcio, G., Palazzo, G., Torsi, L. Characterization of Covalently Bound Anti-human Immunoglobulins on Self-assembled Monolayer Modified Gold Elec-trodes.Advanced Biosystem, 2017,1, 1700055.
(2016) Macchia E, Alberga D, Manoli K, Torsi L, et al. Organic bioelectronics probing conformational changes in surface confined proteins. Scientific Reports 6,28085. 
(2015) Macchia E, Giordano F, Magliulo M, Torsi L, et al. An analytical model for bio-electronic organic field-effect transistor sensors.Applied Physics Letters, 106(2). 
(2015) Afzal A, Di Franco C, Mesto E, Torsi L, et al. Au/In2O3 and Au/ZrO2 composite nanoparticles via in situ sacrificial gold electrolysis.  Materials Express, 5(3):171-179. 
(2015) Mulla M Y, Tuccori E, Magliulo M, Torsi L, et al. Capacitance-modulated transistor detects odorant binding protein chiral interactions, Nature Communications, 6,6010. 
(2015) Palazzo G, De Tullio D, Magliulo M, Torsi L, et al. Detection Beyond Debye's Length with an Electrolyte-Gated Organic Field-Effect Transistor. Advanced Materials, 27(5):911-916. 
(2013) Torsi L et al. Organic field-effect transistor sensors: a tutorial review. Chemical Society Reviews, 42(22):8612-8628. 
(2008) Torsi L, et al. A sensitivity-enhanced field-effect chiral sensor. Nature Materials, 7(5): 412-417. 
(1995) Dodabalapur A, Katz EH, Torsi L, et al. Organic Heterostructure Filed-Effect Transistors.Science, 269 (5230):1560-1562. 
(1995) Dodabalapur A, Torsi L, Katz EH. Organic Transistors - 2 dimensional transport and improved electrical characteristics. Science, 268 (5208):270-271.

 

Awards and prizes

In 2010 she has been awarded with the Heinrich Emanuel Merck prize for analytical sciences, this marking the first time the prestigious award is given to a woman and to an Italian scientist. She is also the recipient of the main overall platinum 2015 prize of the Global-Women Inventors and Innovators Network. She has been also elected 2017 Fellow of the Material Research Society, one of the largest international society in this field, for pioneering work in the field of organic (bio) electronic sensors and their use for point-of-care testing. It is the first scientist to work for an Italian institution to be awarded with this recognition. In 2018 she received the silver medal of the Italian Chemical Society (SCI) awarded at the Merck & Elsevier Young Chemistry Symposium by the “SCI Gruppo Giovani”.

 

 

Margherita Venturi
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STEM area: Chemistry

Competences: supermolecular electrochemistry, supermolecular photochemistry

Keywords: chemical computers, disclosure, energetic conversion, energy, molecular machines, nanosciences, nanotechnologies, shows

Region: Emilia-Romagna


Position/Role

Full professor of General Chemistru at University of Bologna

Professional career

After graduating in Chemistry at the University of Bologna in 1971, she continued her education first as a fellow, then a contractor and finally a researcher at the Faculty of Pharmacy at the University of Bologna until 1992. In the same year she became associate professor in the faculty of Mathematical Sciences , Physics and Natural of the same university, and is confirmed again in 1995. Since 2005 she is full professor of General Chemistry of the University of Bologna.

Scientific results

From 1972 to 1991 she worked at National Research Council of Bologna where her main research activity was focused on the field of Radiation Chemistry. In particular, she studied the electron-transfer processes involved in model systems for the conversion of solar energy in chemical energy. Her present research activity is in the field of Supramolecular Photochemistry and Electrochemistry; specifically she is involved in the realization of systems made by two or more molecules capable of performing useful functions. The aims of the research are the following. 1. The desing and construction of chemical systems where the molecular components display changes in their relative positions as a result of some external stimulus, that can be photochemical, chemical and electrochemical in nature. Such systems are called molecular machines and their importance is testified by the fact that this research topic was awarded the Nobel Prize in Chemistry 2016. 2. The design and construction of systems capable of transferring, switching, collecting, storing, and elaborating photochemical, chemical and electrochemical signals. Up to now several systems of this kind have been obtained, like molecular antennae, wires, plug/socket and extension devices. The results of her research are of great importance in the fields of nanosceince and nanotechnology; for example the developed systems can lead to the construction of molecular devices able to convert solar energy in chemical energy and to elaborate information (chemical computer); they can also find applications in the field of medicine, for example, to develop drug delivering systems that can open new perspectives to treat tumors.

Editorial work and publications

She is co-author of more than 250 scientific papers, including several reviews, published in the most relevant international journals. Five of them are listed below.

1.    (2015) D’Agostino S, Bergamini G, Ceroni P, Comotti A, Sozzani P, Bassanetti I, Grepioni F, Hernandez TM, Silvi S, Venturi M, Credi A. Photoinduced reversible switching of porosity in molecular crystals based on star-shaped azobenzene tetramers. Nature Chemistry, 7:634-640.

2.    (2015) Ragazzon G, Baroncini M, Silvi S, Venturi M, Credi A. Light-powered autonomous and directional molecular motion of a dissipative self-assembling system. Nature Nanotechnology, 10:70-75.

3.    (2008) Balzani V, Credi A, Venturi M. Photochemical conversion of solar Energy. ChemSusChem, 1:26-58.

4.    (2008) Balzani V, Credi A, Venturi M. Molecular Devices and Machines – Concepts and Perspectives for the Nanoworld. Wiley-VCH: Weinheim, 1-546.

5.    (2006) Balzani V, Clemente-León M, Credi A, Ferrer B, Venturi M, Flood A H, Stoddart J F. Autonomous artificial nanomotor powered by sunlight. Proc. Natl. Acad. Sci. USA, 103:1178-1183.

Awards and prizes

In 2014 she received the Gold Medal Gabriello Illuminati from the Italian Chemical Society because of her contribution and involvement in teaching and spreading Chemistry as author of articles and books, as coordinator and partner of national and European projects, and as organizer of seminars, scientific exhibits, and teacher training courses. In addition, the medal recognized the fact that in 2000 she began to organize at the Department of Chemistry “Giacomo Ciamician” a show entitled Sounds, Lights, Colors and Other Special Effectsduring which the attending students (from primary to high schools) and citizens can see chemical demonstrations and understand the importance, utility, and beauty of Chemistry.